TABLE 2.
Parameters indicative of PEG allergy in patients in our study and comparison to a review and a large case series in the literature
| Parameter | PEG allergy in this study | Wenande et al. 1 | Bruusgaard et al. 6 |
|---|---|---|---|
| Gender (f/m) | 7/3 | 14/23 | 6/4 |
| Age (y: median, range) | 38.5 (12–77) | 24–86 | 35 (18–64) |
| Time interval a (min) | 18.5 (4–30) | “Rapid in onset within minutes” | <10 min |
| Elicitors b (n) |
Laxatives/bowel preparations (3) Analgetic tablets (2) Injectable contraceptive (2) Antibiotic tablets/sirup (2) Calcium or vitamin effervescent tablet (2) Cold medicine lozenge/syrup (2) Injectable corticosteroid (1) Iodine solutions (1) Chlorhexidine disinfectant (1) |
Laxatives/bowel preparations 20/37 (54%), corticosteroids, vitamins/minerals, throat lozenges, ultrasound gels, disinfectants, antiepileptics, antiemetics, anticoagulants, antidepressants, analgesics, antibiotics, anti‐inflammatory drugs, reflux medication toothpaste, dental floss, creams, shampoos, paint, wound dressings, tissue sealants, hydrogels |
Oral medication (analgesics, antacids, antibiotic tablets) Injections Laxatives Cough medicine Cream/ointment, shaving products, hand soap, toothpaste, mouth wash, dental floss, hair products (shampoo, coloring), make‐up, make‐up remover, vaseline, epoxy, cleaning agent |
| Patients >1 reaction n (%) | 4 (40) | 16 (43) | 7 (70) |
| Severe anaphylaxis c n (%) | 2 (13) | 14 (38) | 8 (80) |
| Anaphylaxis n (%) | 15 (100) | 28 (78) | 8 (80) |
| Urticaria b n (%) | 14 (93) | 44 (66) | ns |
| Skin/mucosal reaction b n (%) | 15 (100) | 62 (92) | ns |
| Most frequent symptoms b n (%) | Generalized skin reaction 15 (100), dyspnea 6 (60), angioedema 3 (20) | Pruritus, tingling, flushing, urticaria, angioedema, hypotension, and bronchospasm | Urticaria, itching, flushing, discomfort, angioedema, breathlessness, burning sensation, and fainting |
Abbreviation: ns, not specified.
Time interval from exposure to reaction.
Individual episodes counted separately.
Severe anaphylaxis according to Ring and Messmer grades III and IV.