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. 2022 Jan 24;17(5):e202101149. doi: 10.1002/asia.202101149

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© 2022 Wiley‐VCH GmbH

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Modes of synergistic activities of hypothetical drug A and drug B which includes induction of conformational change of the drug target (a), enhances drug uptake (b), Interaction within drugs that triggers activity (c), blocking the drug antagonists (d), blocking the different steps of the same reaction (e) and changing microenvironment like solubility or pH (f).