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. 2022 Apr 15;23(Suppl 4):130. doi: 10.1186/s12859-022-04663-5

Table 1.

Summary of the performance tables and collected data sets for 10 kinase families

Group Family Accuracy Sensitivity Specificity MCC No. of inhibitors No. of non-inhibitor
TK VEGFR 0.86 ± 0.06 0.73 ± 0.12 0.93 ± 0.06 0.68 ± 0.16 387 744
PDGFR 0.92 ± 0.06 0.75 ± 0.22 0.94 ± 0.02 0.78 ± 0.17 150 499
JAK 0.94 ± 0.02 0.95 ± 0.05 0.91 ± 0.03 0.86 ± 0.07 1551 874
FGFR 0.9 ± 0.06 0.76 ± 0.13 0.93 ± 0.04 0.75 ± 0.13 263 584
AGC AKT 0.94 ± 0.03 0.94 ± 0.06 0.95 ± 0.04 0.87 ± 0.08 391 768
PKG 0.92 ± 0.07 0.62 ± 0.08 0.96 ± 0.02 0.6 ± 0.25 61 390
CAMK PIM 0.92 ± 0.03 0.92 ± 0.06 0.91 ± 0.06 0.84 ± 0.07 766 617
PKD 0.86 ± 0.09 0.56 ± 0.07 0.92 ± 0.04 0.63 ± 0.11 79 442
CMGC CLK 0.8 ± 0.08 0.63 ± 0.08 0.89 ± 0.1 0.57 ± 0.06 201 392
GSK 0.81 ± 0.07 0.57 ± 0.04 0.91 ± 0.05 0.59 ± 0.07 260 639