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. 2022 Apr 15;22:106. doi: 10.1186/s12866-022-02515-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Celastrol altered the expression of S. aureus genes. RT-qPCR revealed decreased expression of STX and biofilm related genes in celastrol treated S. aureus relative to untreated bacteria. The expression levels of crtM, crtN, sigB, katA, sodM, sodA, sarA, agrA, icaA, icaR, msaB and yjbH were analyzed by qRT-PCR in both celastrol treated and untreated S. aureus. The data shown are the means ± standard errors from triplicate experiments with three technical replicates each. A P value < 0.05 was considered statistically significant using Student’s t test