Table 2.
MICs and FICIs of celastrol and tested antibiotics against S. aureus ATCC 6538
Agent | MIC (μg∕mL) | FIC | FICI | Interpretation | |
---|---|---|---|---|---|
Alone | Combination | ||||
Celastrol | 1 | 0.25 | 0.25 | 0.31 | S |
Ampicillin | 8 | 0.5 | 0.06 | ||
Celastrol | 1 | 0.25 | 0.25 | 0.31 | S |
Cefotaxime | 4 | 0.25 | 0.06 | ||
Celastrol | 1 | 0.06 | 0.06 | 0.12 | S |
Azithromycin | 1 | 0.06 | 0.06 | ||
Celastrol | 1 | 0.06 | 0.06 | 0.185 | S |
Ciprofloxacin | 2 | 0.25 | 0.125 | ||
Celastrol | 1 | 0.06 | 0.06 | 0.12 | S |
Gentamycin | 2 | 0.12 | 0.06 |
FIC Fractional inhibitory concentration, FICI Fractional inhibitory concentration index, S Synergism