Table 3.
The treatment protocol and laboratory test of infants with or without red blood cell transfusion post diagnosis of NEC
| Variables | Red Blood Cell Transfusion post NEC diagnosis | ||
|---|---|---|---|
| With (n = 60) | Without (n = 182) | P | |
| Albumin transfusion, %(n) | 68.3 (41) | 29.7 (54) | 0.000 |
| Transfusion prior to NEC diagnosis, %(n) | 16.7 (10) | 2.7 (5) | 0.000 |
| Fresh frozen plasma transfusion post NEC diagnosis, %(n) | 25.0 (15) | 2.2 (4) | 0.000 |
| Platelet transfusion post NEC diagnosis, %(n) | 11.7 (7) | 1.6 (3) | 0.003 |
| Cryoprecipitate transfusion post NEC diagnosis, %(n) | 16.7 (10) | 4.4 (8) | 0.004 |
| Intravenous immunoglobulin, %(n) | 15.0 (9) | 3.8 (7) | 0.007 |
| Probiotics use, %(n) | 48.3 (29) | 50.5 (92) | 0.766 |
| Anaerobic antimicrobial therapy, %(n) | 90.0 (54) | 62.6 (114) | 0.000 |
| Vasoactive agents support, %(n) | 41.7 (25) | 17.0 (31) | 0.000 |
| Mechanical ventilation, %(n) | 6.7(4) | 0(0) | 0.001 |
| Broad spectrum antibiotics use [days, median (IQR)] | 18 (12–24) | 12 (9–16) | 0.000 |
| Cessation of enteral feeding [days, median (IQR)] | 8.5 (6–13.75) | 7 (4–9) | 0.000 |
| Gastrointestinal decompression [days, median (IQR)] | 6 (1.25–9) | 1 (0–4.25) | 0.000 |
| WBC counta < 5 × 109/L or > 20 × 109/L, %(n) | 20.0 (12) | 15.9 (29) | 0.467 |
| Platelet counta < 100 × 109/L, %(n) | 11.7 (7) | 7.7 (14) | 0.343 |
| CRPa > 8 mg/L, %(n) | 46.7 (28) | 27.5 (50) | 0.006 |
| Lowest Hct b (%, mean ± SD) | 25.8 ± 4.1 | 35.1 ± 6.4 | 0.000 |
aThe baseline values were tested within 24 h of NEC diagnosis
bThe Lowest Hct post NEC diagnosis and prior NEC deterioration
WBC White blood cell, CRP C-reactive protein, NEC Necrotizing enterocolitis, Hct Hematocrit, SD Standard deviation, IQR Interquartile range