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. 2022 Mar 15;208(6):1341–1351. doi: 10.4049/jimmunol.2101041

FIGURE 1.

FIGURE 1.

Loss of IFNL signaling reduces severity of CNS autoimmune disease. (A) EAE clinical course and area under the curve (AUC) analysis following active immunization with MOG35-55 peptide of WT and Ifnlr1−/− mice. Data are pooled from two independent experiments; n = 11 WT and n = 14 Ifnlr1−/− animals shown. (B) IF analysis of lesions within the ventral lumbar spinal cord of WT and Ifnlr1−/− mice during EAE at chronic time point indicated in (A). Iba1+ and SMI-32+ areas were quantified. Data are pooled from two independent experiments; n = 10 WT and n = 14 Ifnlr1−/− animals shown. Scale bar, 20 μm. Data are presented as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 by Mann-Whitney U test (A) and two-tailed Student t test (A and B).