FIGURE 3.

MZ B cell depletion is partially rescued and infiltration of Ly6C^hi monocytes into the spleen is impaired in CCR2KO mice. (A–D) Percentage of (A) CD19⁺ splenic B cells, (B) MZ B cells, (C) Ly6C^hi, and (D) Ly6C^lo in C57BL/6 WT or CCR2KO mice treated with PBS or IgG isotype control or anti-CD47 Ab, as described in Materials and Methods. Data are representative of two independent experiments with three to four mice per group (A and B) and one experiment with three to five mice per group (C and D). Groups were compared with an unpaired, two-tailed t test with Welch’s correction. Data are presented as the mean ± SEM. ***p < 0.001, ****p < 0.0001; ns, not significant.