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. Author manuscript; available in PMC: 2022 Sep 23.
Published in final edited form as: J Med Chem. 2021 Sep 13;64(18):13902–13917. doi: 10.1021/acs.jmedchem.1c01294

Figure 1.

Figure 1.

A) BPTF interacts with chromatin through the bromodomain (BRD) and PHD domain, directing the chromatin remodelling complex NURF to genes, leading to downstream phenotypic effects such as Myc regulation, MAPK signaling and resistance to chemotherapeutics. B) Part of the bromodomain phylogenetic tree, showing class I and class II (BET) bromodomains (adapted with permission from Pomerantz et al.11). C) Reported BPTF bromodomain inhibitors with in vitro affinities.