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. Author manuscript; available in PMC: 2022 Sep 23.
Published in final edited form as: J Med Chem. 2021 Sep 13;64(18):13902–13917. doi: 10.1021/acs.jmedchem.1c01294

Figure 2.

Figure 2.

Cocrystal structure of GSK4027 (cyan) with BPTF bromodomain (gray, PDB: 7K6R). Four conserved structured waters are shown as red spheres. Hydrogen bonds are shown as yellow dashed lines and aromatic interaction as orange dashed line. The distances (Å) between key residues are indicated. Inset: Residues in other class I bromodomains (PCAF, GCN5 and CECR2) corresponding to D2957 and D2960 in BPTF.