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. Author manuscript; available in PMC: 2022 Sep 23.
Published in final edited form as: J Med Chem. 2021 Sep 13;64(18):13902–13917. doi: 10.1021/acs.jmedchem.1c01294

Figure 3.

Figure 3.

BPTF bromodomain (gray) cocrystal structures with A,B) 10 (magenta, PDB: 7RWP, 1.73 Å resolution), C) 12 (yellow, PDB: 7RWQ, 1.90 Å resolution), D) 13 (orange, PDB: 7RWO, 1.58 Å resolution) and E) 19 (blue, PDB ID: 7M2E, 1.75 Å resolution). Hydrogen bonds are shown as yellow dashed lines. The distances (Å) between key residues are indicated. Three of the conserved structured waters are excluded for clarity.