Table 3:

SAR with aromatic pyridazinones containing different basic groups substitutions for binding to BPTF

	R	BPTF AlphaScreen IC50 (μM)	L.E.
10		0.29 ± 0.08	0.50
11		0.31	0.44
12		0.25	0.45
13		0.37	0.44
14		3.9	0.37
15		0.80	0.46
16		0.22	0.50
17		0.97	0.39

AlphaScreen values were an average of two technical replicates with N = 1, except for 10 where it was an average of three experimental replicates. Binding isotherms shown in Figure S3.