Table 4.
Independent predictors of recurrent relapse with multivariate Anderson and Gill model.
| Independent predictors | Model | |
|---|---|---|
| Hazard ratio (95% CI) | p-value | |
| Female gender (Reference = male) | 1.37 (1.01-1.86) | 0.042* |
| AQP4-ab titer (Reference = < 1:100) | 1.28 (1.06-1.55) | 0.010* |
| Previous attack under same therapy (Reference = no) | 1.32 (1.08-1.61) | 0.007** |
| EDSS score at treatment initiation (Reference = < 2.5) | 0.80 (0.66-0.97) | 0.023* |
| Maintenance therapy (Reference=no or prednisone < 6 months) | ||
| Prednisone (≥ 6 months) | 0.29 (0.14-0.59) | < 0.001*** |
| AZA | 0.42 (0.32-0.56) | < 0.001*** |
| MMF | 0.35 (0.24-0.50) | < 0.001*** |
| TAC | 0.37 (0.21-0.64) | < 0.001*** |
| RTX | 0.20 (0.11-0.36) | < 0.001*** |
| CTX | 0.86 (0.38-1.92) | 0.71 |
| C-index | ||
| Primary cohort | 0.66 (0.64-0.69) | |
| Validation cohort | 0.65 (0.60-0.70) | |
AQP4-ab, aquaporin-4 antibody; EDSS, Expanded Disability Status Scale; AZA, azathioprine; MMF, mycophenolate mofetil; TAC, tacrolimus; RTX, rituximab; CTX, cyclophosphamide. *p < 0.05, **p < 0.01, ***p < 0.001.