TABLE 1.
Demographic Information for Incident PD Cases and Controls After Exclusions
| Excluded individuals | Matched analysis | Unmatched analysis | ||||
|---|---|---|---|---|---|---|
| Controls (n = 172,582) | Cases (n = 1,201) | Controls (n = 1,860) | Cases (n = 465) | Controls (n = 312,125) | Cases (n = 465) | |
| Age at PD report | NA | 69.65 (5.7) | NA | 68.52 (6.82) | NA | 68.52 (6.82) |
| Age at recruitment | 58.99 (7.46) | 63.58 (5.18) | 62.4 (5.81) | 62.4 (5.82) | 55.21 (8.1) | 62.4 (5.82) |
| Townsend score | −1.2 (3.15) | −1.16 (3.21) | −1.52 (3.05) | −1.51 (2.94) | −1.36 (3.06) | −1.51 (2.94) |
| Sex | ||||||
| F | 95,510 (55.35%) | 317 (41.22%) | 636 (34.19%) | 159 (34.19%) | 167,951 (53.81%) | 159 (34.19%) |
| M | 77,062 (44.65%) | 452 (58.78%) | 1,224 (65.81%) | 306 (65.81%) | 144,174 (46.19%) | 306 (65.81%) |
| Self-reported ethnic background | ||||||
| Non-While | 7,067 (4.12%) | 31 (4.05%) | 72 (3.89%) | 12 (2.61%) | 18,406 (5.93%) | 12 (2.61%) |
| White | 164,518 (95.88%) | 735 (95.95%) | 1,778 (96.11%) | 448 (97.39%) | 292,189 (94.07%) | 448 (97.39%) |
| Country of birth | ||||||
| Do not know | 47 (0.03%) | 0 (0%) | 0 (0%) | 1 (0.22%) | 90 (0.03%) | 1 (0.22%) |
| Elsewhere | 11186 (6.49%) | 47 (6.14%) | 124 (6.67%) | 24 (5.18%) | 26936 (8.64%) | 24 (5.18%) |
| England | 137,274 (79.69%) | 640 (83.55%) | 1,438 (77.4%) | 362 (78.19%) | 239,966 (76.96%) | 362 (78.19%) |
| Northern Ireland | 1,061 (0.62%) | 8 (1.04%) | 14 (0.75%) | 6 (1.3%) | 1,920 (0.62%) | 6 (1.3%) |
| Prefer not to answer | 204 (0.12%) | 0 (0%) | 1 (0.05%) | 3 (0.65%) | 475 (0.15%) | 3 (0.65%) |
| Republic of Ireland | 2,051 (1.19%) | 10 (1.31%) | 19 (1.02%) | 11 (2.38%) | 2,737 (0.88%) | 11 (2.38%) |
| Scotland | 12,742 (7.4%) | 39 (5.09%) | 174 (9.36%) | 41 (8.86%) | 25,952 (8.32%) | 41 (8.86%) |
| Wales | 7,703 (4.47%) | 22 (2.87%) | 88 (4.74%) | 15 (3.24%) | 13,724 (4.4%) | 15 (3.24%) |
“Unmatched analysis” refers to the entire cohort after exclusion of individuals with potentially confounding comorbidities. “Matched analysis” refers to 1:4 matched controls (matched to incident PD cases by age at recruitment and sex). Demographic data for excluded individuals (excluded due to potentially confounding comorbidities) are also shown. Categorical variables are presented as n (%), and continuous variables as mean (SD).
NA = not applicable; PD = Parkinson’s disease.