TABLE 2.

Association of Blood Cell Traits and Inflammatory Markers with Incident PD

Trait	OR per 1-SD reduction in exposure	p	Adjusted p value (Q, FDR 5%)
Lymphocyte count	1.18 (95% CI = 1.07–1.32)	0.001	0.011
Eosinophil count	1.16 (95% CI = 1.04–1.3)	0.006	0.027
CRP	1.13 (95% CI = 1–1.29)	0.031	0.073
Monocyte count	1.12 (95% CI = 1.01–1.26)	0.032	0.073
Neutrophil count	0.91 (95% CI = 0.84–1)	0.051	0.093
Albumin	1.04 (95% CI = 0.93–1.15)	0.504	0.756
Platelet count	1.02 (95% CI = 0.93–1.13)	0.645	0.829
Total white cell count	1 (95% CI = 0.91–1.1)	0.945	0.979
Basophil count	1 (95% CI = 0.91–1.11)	0.979	0.979

The table shows the odds ratios, confidence intervals, p values from likelihood ratio tests, and FDR Q values for the output of multivariable logistic regression models, modeling incident PD on age + sex + deprivation + ethnicity + trait. Odds ratios represent the predicted effect of a 1 standard deviation (SD) decrease in the trait (ie, a 1 unit decrease in Z score) on the odds of incident PD. For instance, for each 1-SD decrease in lymphocyte count, the odds of PD are predicted to increase by 18%.

CI = confidence interval; CRP = C-reactive protein; FDR = False Discovery Rate; OR = odds ratio; PD = Parkinson’s disease; SE = standard error.