Table 5. Univariate and multivariate Cox analysis for follow-up mortality.
| Variables | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | ||
| Demographic | |||||
| Age | 1.01 (0.99–1.07) | 0.156 | |||
| Female gender | 2.22 (1.20–11.02) | 0.01 | |||
| BMI | 0.95 (0.83–1.08) | 0.414 | |||
| DM | 0.04 (0.00–2.91) | 0.488 | |||
| Cancer history | 3.60 (1.57–10.58) | 0.009 | |||
| Current/past smoking habit | 1.26 (0.45–3.51) | 0.657 | |||
| Hypercoagulability | 1.01 (0.36–2.82) | 0.984 | |||
| PE history | 0.15 (0.06–0.55) | 0.002 | |||
| Clinical | |||||
| WHO functional class III-IV | 2.00 (0.45–9.00) | 0.214 | |||
| 6MWD (increase by 30 m) | 0.70 (0.65–0.85) | <0.001 | 0.80 (0.75–0.94) | 0.009 | |
| Hemodynamic | |||||
| RAP (increase by 10 mmHg) | 0.99 (0.40–2.35) | 0.973 | |||
| mPAP (increase by 10 mmHg) | 1.15 (0.77–1.76) | 0.475 | |||
| PVR (increase by 200 dyn·s·cm−5) | 1.34 (1.10–1.60) | 0.001 | |||
| CO (increase by 0.5 L/min) | 0.62 (0.48–0.82) | 0.001 | 0.61 (0.39–0.96) | 0.033 | |
| Time from diagnosis to surgery | 0.95 (0.93–1.04) | 0.644 | |||
| Residual PH | 1.25 (0.34–4.60) | 0.714 | |||
HR, hazard ratio; CI, confidence interval; BMI, body mass index; DM, diabetes mellitus; PE, pulmonary embolism; WHO, World Health Organization; 6MWD, six-minute walk distance; RAP, right atrial pressure; mPAP, mean pulmonary arterial pressure; PVR, pulmonary vascular resistance; CO, cardiac output; PH, pulmonary hypertension.