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. 2022 Mar 28;12:844691. doi: 10.3389/fonc.2022.844691

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Copyright © 2022 Tang, Lu, Zhu, Zheng, Fang, Ji and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic analysis of four-gene signature in the training cohort, testing cohort and entire cohort. (A, B) The distribution of risk score (A) and patient’s survival time (B) in the training cohort. (C, F, I) Kaplan-Meier survival analysis of the four-gene signature in the training cohort (C), testing cohort (F) and entire cohort (I), respectively. (D, G, J) Time-dependent ROC analysis of the four-gene signature in the training cohort (D), testing cohort (G) and entire cohort (J), respectively. (E, H, K) Principal components analysis (PCA) of whole gene expression data between low- and high-risk groups in the training cohort (E), testing cohort (H) and entire cohort (K), respectively. ROC, receive operating characteristic; AUC, area under curve.