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. 2022 Apr 15;132(8):e151817. doi: 10.1172/JCI151817

Figure 7. Human evidence from the UK Biobank.

Figure 7

(A and B) Relationship between age at death and number of chronic pain sites, in men (A) and women (B). Slanted lines were obtained from linear regression. Box‑and-whiskers show age distributions for each number of pain sites; gold dots indicate means. (C) Gene-level summary statistics for sex-stratified GWAS on number of chronic pain sites. Genes (nomenclature according to the Human Genome Organization [HUGO]) considered were the human analogs of mouse senescence-related genes shown in Figure 4. TP53 is the human analog of Trp53, encoding p53. N, sample size; ZSTAT, z statistic (MAGMA-assigned, gene-level summary test statistic; see Methods); P, 1-sided P value from test statistics; ZZ, difference between the men’s and women’s test statistics (men ZSTAT – women ZSTAT); ZZ_P, P value of ZZ, uncorrected; ZZ_FDR, false discovery rate–corrected P value of ZZ.