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. 2022 Apr 15;132(8):e153167. doi: 10.1172/JCI153167

Figure 1. WHSC1 is negatively associated with disease outcome in CRC.

Figure 1

(A) Kaplan-Meier plot of overall survival and DFS, grouped by WHSC1 mRNA levels using TCGA and GSE41258 data sets. (B) Relative mRNA expression of WHSC1 in paired normal and tumor tissues (n = 27). WHSC1 expression was normalized to the mean level in the normal counterpart tissues. (C) Kaplan-Meier plot of overall survival and DFS stratified by WHSC1 IHC score using the Fudan TMA (n = 172). WHSC1 IHC scores were based on a multiplicative index of the average staining intensity (1 to 3) and the extent of staining (1 to 3). Scale bar: 50 μm. (D) Correlations between WHSC1 levels and tumor stages in the Fudan TMA (n = 172). The width of each curve in the violin plot corresponds to the approximate frequency. The solid and dotted lines show the median and quartile values, respectively, with the whiskers extending to the largest and smallest values. *P < 0.05 and **P < 0.01, by log-rank test (A and C), paired Student’s t test (B), and Kruskal-Wallis test followed by multiple comparisons (D).