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. 2022 Apr 15;132(8):e151725. doi: 10.1172/JCI151725

Figure 3. The liver microbiome varies with age.

Figure 3

(A–D) We comparatively analyzed the hepatic microbiome in female mice aged 6, 12, 24, and 48 weeks by 16S rRNA-Seq. Taxonomic composition of microbiota in the liver were assigned to phylum (A) and genus (B) levels based on average percentage of relative abundance. Weighted PCoA plots from each cohort were based on the Bray-Curtis dissimilarity matrix (C), and changes in α-diversity measures compared with 6 weeks (D) are shown. n = 5/group. *P < 0.05; **P < 0.01; ***P < 0.001. Bact., Bacteroidetes; Firm., Firmicutes; Proteo., Proteobacteria; Verruc., Verrucomicrobia.