Table 3.
Comparison of Changes in Anemia and Iron Indices and in Anemia Therapies
| Parameter | Baseline | Follow-Up | P value | |||
|---|---|---|---|---|---|---|
| −Q1; ref | Q1 | Q2 | Q3 | Q4 | ||
| Anemia and iron indices | ||||||
| Ferritin (ng/mL) | 1009 (12) | 1042 (12)b | 1094 (12)c | 1114 (12)c | 1138 (12)c | <0.0001 |
| TSAT (%) | 33.2 (0.2) | 34.8 (0.2)c | 35.7 (0.2)c | 35.4 (0.2)c | 35.4 (0.2)c | <0.0001 |
| Hemoglobin (g/dl) | 10.91 (0.02) | 10.96 (0.02)c | 10.92 (0.02) | 10.93 (0.02) | 10.94 (0.02)a | <0.0001 |
| Anti-anemia therapy | ||||||
| IV iron sucrose use (%) | 77.7 | 77.2 | 73.4b | 71.2c | 69.4c | <0.0001 |
| IV ESA use (%) | 85.6 | 86.2 | 84.7 | 83.4a | 83.3a | <0.0001 |
Notes: Unless specified, values are presented as least-squares mean (standard error). P values compare summary estimates across time with −Q1 as the reference. Overall P values were calculated using linear mixed-effects regression (continuous variables) or Cochran’s Q test (categorical variables). aP < 0.05; bP < 0.001; cP < 0.0001 (vs baseline).
Abbreviations: ESA, erythropoiesis-stimulating agent; IV, intravenous; TSAT, transferrin saturation.