Table 1.
Effect of linagliptin on rotenone-induced alterations on antioxidant assays in brain homogenate
| Groups | SOD (reduced NBT pM/min/mg) | Catalase (µM of H2 O2 oxidized/minute/mg protein) | GSH (µmol/mg protein) |
|---|---|---|---|
| Normal control | 0.035±0.0010 | 5.97±0.95 | 3.10±0.46 |
| Disease control | 0.010±0.0010# | 0.65±0.28# | 1.14±0.11# |
| Standard control | 0.019±0.0023* | 4.10±0.59* | 2.40±0.37* |
| Linagliptin (5 mg/kg) | 0.013±0.0020* | 4.41±1.26* | 2.57±0.22* |
| Linagliptin (10 mg/kg) | 0.026±0.0020* | 4.86±0.71* | 3.06±0.46* |
| Linagliptin (20 mg/kg) | 0.018±0.0010* | 4.60±0.86* | 2.61±0.14* |
H2 O2=Hydrogen peroxide, SOD=Superoxide dismutase, NBT=Nitroblue tetrazolium, GSH=Glutathione. All values are expressed as Mean±SEM. # p< 0.05 and *p< 0.05