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. 2022 Apr 11;9:301–313. doi: 10.2147/JHC.S355540

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© 2022 Hsueh et al.

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Additive joint effect between excess BMI, PNPLA3 148M-variant, and hepatic steatosis on the probability of HBsAg seroclearance. (A) Cumulative incidence function curve of HBsAg seroclearance according to a prognostic score ranging from 0 to 5 (points: BMI [normal weight/underweight=0, overweight=1, obesity=2]; PNPLA3 [II=0, MI=1, MM=2]; steatosis [No=0, yes=1]). (B) Sub-distribution hazard ratios (sHRs) with 95% CIs estimated from competitive risk Cox model. Solid circles and lines indicated sHRs and 95% CIs. sHRs derived from the entire cohort were adjusted for age, ALT, history of liver disease, diabetes, cigarette smoking, and alcohol consumption. sHRs derived from the subcohort were further adjusted for HBeAg, viral load, HBV genotype (C vs non-C), and BCP double mutations.