Table 2.

Baseline Factors Associated with HBsAg Seroclearance

Variable	Entire Cohort (N=2385)									Subcohort (N=919)
	Total No.	No. of HBsAg Seroclearance	Cumulative Incidence, %		Univariate Analysisa			Multivariate Analysisb		Multivariate Analysisc
			10-y	20-y	sHR	95% CI	p-value	sHR	95% CI	sHR	95% CI
Hepatic steatosis
No	1293	300	10.0	23.6	1.0			1.0		1.0
Yes	1092	328	13.7	33.2	1.43	(1.22–1.67)	<0.0001	1.27	(1.07–1.50)	1.35	(1.03–1.78)
BMI (kg/m2)
Normal weight/underweight (<23)	932	192	8.3	22.2	1.0			1.0		1.0
Overweight (23–24.9)	729	214	13.1	31.5	1.50	(1.23–1.82)	<0.0001	1.47	(1.20–1.80)	1.55	(1.10–2.19)
Obesity (≥25)	724	222	14.7	31.3	1.58	(1.30–1.92)	<0.0001	1.55	(1.26–1.91)	1.51	(1.09–2.09)
PNPLA3d
II	940	221	9.2	25.7	1.0			1.0e		1.0f
MI	1103	310	13.2	29.5	1.19	(1.01–1.42)	0.0429	1.19	(1.00–1.41)	1.35	(1.00–1.81)
MM	337	95	13.4	28.5	1.25	(0.98–1.59)	0.0688	1.25	(0.98–1.59)	1.42	(0.95–2.13)
HBeAg
Negative										1.0
Positive										0.42	(0.21–0.85)
HBV DNA (log copies/mL) (continuous)										0.85	(0.79–0.90)
HBV genotype
B or B+C										1.0
C										2.09	(1.49–2.93)
BCP double mutations
No										1.0
Yes										1.27	(0.96–1.67)

Notes: ^aAdjusted for age at baseline. ^bAdjusted for age (continuous), ALT (continuous), history of liver disease, diabetes, cigarette smoking (non-smokers, ex-smokers, current smokers), alcohol consumption, and variables listed in the table ^cAdjusted for age (continuous), ALT (continuous), and variables listed in the table ^d5 subjects with missing data on PNPLA3 genotype. ^ep-value for trend=0.0316. ^fp-value for trend=0.0376.

Abbreviations: sHR, sub-distribution hazard ratio; BCP, basal core promoter.