Table 3.

Multivariate-Adjusted sHRs of HCC Derived from the Entire Cohort and the Case-Cohort Analysis

Variable	Entire Cohort (N=2385)				Case-Cohort Analysis (N=961)
	No. of HCC	sHRa	95% CI	p-value	HRb	95% CI	p-value
HBsAg seroclearance
No	192	1.0			1.0
Yes	25	0.33	(0.21–0.50)	<0.0001	0.44	(0.23–0.82)	0.0107
Baseline hepatic steatosis
No	149	1.0			1.0
Yes	68	0.49	(0.36–0.66)	<0.0001	0.53	(0.33–0.86)	0.0096
Baseline BMI (kg/m2)
Normal weight/underweight (<23)	79	1.0
Overweight (23–24.9)	69	1.34	(0.95–1.88)	0.0948	1.0c
Obesity (≥25)	69	1.51	(1.07–2.13)	0.0193	1.85	(1.18–2.89)	0.0072
PNPLA3
II	65	1.0d			1.0e
MI	115	1.64	(1.20–2.25)	0.0019	1.61	(1.00–2.60)	0.0500
MM	37	1.83	(1.20–2.78)	0.0052	2.22	(1.13–4.35)	0.0206
Baseline diabetes
No	207	1.0			1.0
Yes	10	1.43	(0.73–2.80)	0.3000	3.71	(1.50–9.19)	0.0046
Baseline HBV DNA (log copies/mL) (continuous)					1.37	(1.23–1.52)	<0.0001
Baseline HBV genotype
B or B+C					1.0
C					3.16	(2.01–4.96)	<0.0001
Baseline BCP double mutations
No					1.0
Yes					2.32	(1.45–3.70)	0.0004

Notes: ^aAdjusted for age (continuous), ALT (≥40 vs <40 U/L), history of liver disease, first-degree family history of HCC, cigarette smoking (non-smokers, ex-smokers, current smokers), and alcohol consumption at baseline, and variables listed in the table ^bDerived from a weighted Cox regression model adjusted for age (continuous), ALT (≥40 vs <40 U/L), history of liver disease, and first-degree family history of HCC at baseline, and variables listed in the table ^cBMI<25 kg/m² was used as reference group. ^dp-value for trend=0.0006. ^ep-value for trend=0.0090.

Abbreviations: sHR, sub-distribution hazard ratio; BCP, basal core promoter.