TABLE 12.
Baseline, training response, and familial aggregation of measures of oxidative stress in Whites of the HERITAGE Family Study.
| Oxidative Stress Trait | Baseline | Training Response | ||||||
|---|---|---|---|---|---|---|---|---|
| Familial Aggregation | Familial Aggregation | |||||||
| n | Mean (SD) | F | H 2 | Mean (SD) | Training Effect (P Value) | F | H 2 | |
| Plasma glutathione (μmol·L−1) | 142 | 4.5 (1.5) | 2.56 | 0.44 | 0.04 (1.8) | NS | 3.20 | 0.46 |
| Erythrocyte antioxidant enzyme GSH-Px (U·g−1 hemoglobin erythrocyte) | 109 | 57.2 (15.4) | 6.09 | 1.00 | −0.5 | NS | NS | 0.002 |
| Resistance to hemolysis (C50-AAPH; mmol·L−1) |
106 | 75.9 (14.0) | 3.06 | 0.36 | 3.6 (16.1) | 0.02 | 2.08 | 0.35 |
| LDL oxidation lag phase (min) | 71 | 58.4 (23.3) | 3.12 | 0.38 | 6.2 (38.9) | NS | 2.97 | 0.84 |
| LDL oxidation propagation rate (nmol·mg−1 LDL·min−1) | 71 | 8.9 (2.6) | 2.02 | 0.31 | 0.3 (4.0) | NS | 2.12 | 0.44 |
| Plasma TBARS (nmol MDA·mL−1) | 138 | 1.9 (0.7) | 3.19 | 0.43 | −0.04 (0.9) | NS | 3.15 | 0.51 |
Mean values and training response P values have not been adjusted for any covariates. F ratio compares the between-family with the within-family variances and thus provides an estimate of familial resemblance. H2 is the heritability coefficient.
NS, not significant (P > 0.05).
Adapted with permission from Blache et al. (127) and unpublished data.