TABLE 13.
Effects of the endurance exercise program on vastus lateralis muscle fiber type, capillarity per fiber, and enzyme activities, and the familial aggregation of the training response.
| Training Effect | Familial Aggregation of Training Response | ||||
|---|---|---|---|---|---|
| Muscle Trait | Pretraining | Training Response | P | F Ratio | P |
| % type 1 | 43.2 (11.8) | 3.5 (9.4) | 0.003 | 0.62 | NS |
| % type 2 A | 36.8 (8.9) | 1.8 (9.9) | NS | 1.81 | 0.057 |
| % type 2B | 20.0 (11.2) | −5.4 (10.3) | 0.0001 | 1.13 | NS |
| Type 1 caps | 4.58 (0.81) | 0.76 (0.72) | 0.0001 | 1.65 | 0.09 |
| Type 2A caps | 4.40 (1.00) | 0.63 (0.77) | 0.0001 | 1.75 | 0.07 |
| Type 2B caps | 3.47 (1.00) | 0.55 (0.68) | 0.0001 | 0.99 | NS |
| CK | 389 (68) | 27 (69) | 0.0009 | 3.97 | 0.0001 |
| PHOS | 19.9 (4.9) | 1.6 (3.3) | 0.0001 | 2.14 | 0.017 |
| HK | 2.5 (0.5) | 0.4 (0.5) | 0.0001 | 4.01 | 0.0001 |
| PFK | 57.3 (13.9) | 4.9 (10.6) | 0.0002 | 1.85 | 0.043 |
| GAPDH | 422 (94) | 7 (66) | NS | 2.39 | 0.007 |
| LPL | 0.87 (0.27) | −0.01 (0.28) | NS | 1.35 | NS |
| CPT | 0.12 (0.02) | 0.05 (0.02) | 0.0001 | 2.47 | 0.006 |
| HADH | 16.2 (3.0) | 4.6 (3.0) | 0.0001 | 2.13 | 0.017 |
| CS | 11.5 (2.1) | 5.7 (2.5) | 0.0001 | 2.73 | 0.002 |
| COX | 7.0 (1.7) | 2.9 (2.5) | 0.0001 | 2.07 | 0.021 |
Mean and (SD). F ratio of the between- to within-family variance components. Number of subjects ranged from 60 to 78 depending on the muscle trait. The Vmax of enzymes was expressed in micromoles of substrate per gram of wet weight tissue per minute. Total muscle LPL was expressed as nanomicromoles of FFA transformed per gram of wet weight tissue per minute.
NS, not significant (P > 0.05); caps, number of capillaries per fiber; CK, creatine kinase; PHOS, phosphorylase; HK, hexokinase; PFK, phosphofructokinase; GAPDH, glyceraldehyde phosphate dehydrogenase; LPL, lipoprotein lipase; CPT, carnitine palmitoyl transferase; HADH, 3-beta-hydroxyacyl CoA dehydrogenase; CS, citrate synthase; COX, cytochrome c oxidase.