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. 2022 Apr 1;13:887330. doi: 10.3389/fphar.2022.887330

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Copyright © 2022 Zhang, Zheng, Luo, Lin, Que, Wang, Huang, Yang, Ye and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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lncRNA NR-133666 is highly expressed in the cytoplasm of CIA FLS and promotes CIA FLS proliferation and migration. (A) qRT-PCR showed that NR-133666 was increased in CIA FLS. (B) RNA-FISH localization of NR-133666 in CIA FLS. (C) qRT-PCR showed that NR-133666 was reduced in si-NR-133666-transfected macrophages, among them si-NR-133666-1 was the most obvious. (D) MTT showed that the proliferation of si-NR-133666-1 transfected CIA FLS was reduced. (E,F) EdU assay showing CIA FLS proliferation decreased after transfection with si-NR-133666-1 (100×). (G,H) The migratory ability of CIA FLS cells was weakened after transfection with si-NR-133666-1, measured by wound healing assay (100×). Compared with controls, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.