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. 2022 Apr 1;13:887330. doi: 10.3389/fphar.2022.887330

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Copyright © 2022 Zhang, Zheng, Luo, Lin, Que, Wang, Huang, Yang, Ye and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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lncRNA NR-133666 behaves like a sponge for miR-133c. (A) qRT-PCR showed that miR-133c was increased in CIA FLS. (B) qRT-PCR showed that NR-133666 was increased in pIRES NR-133666-transfected CIA FLS. (C) The expression of miR-133c in si-NR-133666–1 and pIRES NR-133666 groups. (D) The predicted binding site between miR-133c and NR-133666. (E) Co-transfection of lncRNA NR-133666 WT and miR-133c mimics decreased luciferase activity. Compared with controls, ***p < 0.001, ****p < 0.0001; compared with pIRES NC, ^## p < 0.01, ^### p < 0.001.