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. 2022 Apr 1;13:887330. doi: 10.3389/fphar.2022.887330

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Copyright © 2022 Zhang, Zheng, Luo, Lin, Que, Wang, Huang, Yang, Ye and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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. lncRNA NR-133666 regulates the proliferation and migration of CIA FLS by regulating miR-133c. (A) qRT-PCR showed that miR-133c was increased in miR-133c agomir-transfected CIA FLS. (B) MTT was performed to verify the effect of miR-133c overexpression, NR-133666 overexpression and co-expression groups on CIA FLS proliferation. (C,D) EdU assay showed CIA FLS proliferation after transfecting pIRES NR-133666, miR-133c and pIRES NR-133666 +miR-133c groups (100×). (E,F) wound healing assay showed the migratory ability of CIA FLS cells (100×). Compared with controls, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.