TABLE 4.

Comparison of regimens with metronidazole and nitrofurantoin for the eradication of metronidazole-sensitive and -resistant H. pylori from mice

Group	No. of mice	Inoculating suspension	Treatmenta	No. of mice infected with:
				H. pylorib	MTZ-resistant H. pylori	NF-resistant H. pylorid
Control	10	PTB	PTB	0	0	0
1	10	H. pylori SS1	PTB	10	0	0
2	10	H. pylori SS1-11	PTB	10	10	0
3	8	H. pylori SS1	OCM	0e	0	0
4	8	H. pylori SS1-11	OCM	7e	7	0
5	6	H. pylori SS1	OCNf	6e	0	0
6	7	H. pylori SS1-11	OCNf	6	6	0

^aPTB, peptone-trypsin broth; OCM, omeprazole, clarithromycin, and metronidazole; OCNf, omeprazole, clarithromycin, and nitrofurantoin. 

^bNumber of mice infected with H. pylori 1 month after the completion of treatment. 

^cNumber of mice from which metronidazole (MTZ)-resistant strains were isolated. 

^dNumber of mice from which nitrofurantoin (NF)-resistant strains were isolated. 

^eStatistically significant difference (P < 0.001).