Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 8;2022:9129984. doi: 10.1155/2022/9129984

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Jieru Han et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

AT III attenuates LPS-induced mitochondrial dysfunction in IEC-6 cells via AMPK/SIRT1-mediated deacetylation of PGC-1α. (a) The levels of mtDNA were examined by qPCR. (b) The MMP changes were measured and quantified by the flow cytometry assay using JC-1 probes. (c, d) The complex I and complex IV activities were measured. (e, f) The protein expression levels of PGC-1α, NRF-1, NRF-2, and Tfam were detected and quantified by Western blot. (g, h) The protein expression levels of p-AMPK, AMPK, and SIRT1 were examined and quantified by Western blot. (i, j) The acetylated levels of PGC-1α and quantification results were determined. ^$p < 0.05, compared to control; ^&p < 0.05, compared to LPS.