Table 3.

Summary of Overall Response and Duration of Responses per Blinded Independent Central Review in CodeBreaK 100

Efficacy parameter	Primary Efficacy Population N = 124	Post-chemotherapy and Immunotherapy Population N = 100
Dose expansion portion (N = 124)
Overall response rate, n (%)	45 (36)	31 (31)
Clopper-Pearson 95% CI	(28, 45)	(22, 41)
Complete Response	3 (2.5)	1 (1.0)
Duration of Response (DOR)
Median, months (95% CI)	10.0 (6.9, NE)	10 (6.9, NE)
Range, months	(1.3+, 11.1)	(1.3+, 11.1)
N (%) w/DOR ≥ 6 months	26 (58)	18 (58)

CI: confidence interval; NE: not estimable

Source: LUMAKRAS (sotorasib) package insert (ref 16)