Table 5.

Sensitivity of predicted albumin uptake under nephrotic conditions to model parameters

	Filtration (mg/day)	Fractional excretion	Total uptake (mg/day)	% via S1	% via S2	% via S3
Impact of GFR
No decrease in GFR	308.8	65.2%	107.3 31.0% via cubilin, 67.6% via megalin, 1.4% via fluid-phase	41.8	55.1	3.1
35% decrease in GFR	200.7	54.8%	90.7 31.1% via cubilin, 67.4% via megalin, 1.5% via fluid-phase	41.4	55.5	3.1
50% decrease in GFR	154.4	46.2%	83.0 31.3% via cubilin, 67.2% via megalin, 1.5% via fluid-phase	41.4	55.4	3.2
Impact of filtrate concentration
10-fold increase in filtrate concentration*	2007	93.5%	129.5 23.3% via cubilin, 62.6% via megalin, 14.1% via fluid-phase	38.0	58.4	3.6
Direct contribution of receptors
No cubilin*	200.7	67.8%	64.6 97.6% via megalin, 2.4% via fluid-phase	31.3	64.6	4.0
No megalin*	200.7	85.0%	30.1 94.4% via cubilin, 5.6% via fluid-phase	60.0	38.3	1.7
No cubilin, no megalin*	200.7	99.1%	1.9 100% via fluid-phase	23.0	70.9	6.1

^*Assuming a 35% decrease in GFR.