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. 2022 Apr 15;12:6283. doi: 10.1038/s41598-022-10182-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MSI signatures. (a) MAP signature and UCEC MSI signature on TCGA-UCEC. (b) MAP signature and STAD MSI signature on TCGA-STAD. (c) MAP signature and preMSIm signature on TCGA-COADREAD. (d) MAP signature and preMSIm signature on TCGA-STAD. (e) MAP signature and preMSIm signature on TCGA-UCEC. The x-axis represents log₂ fold changes in gene expression data for MSI versus MSS samples. The colored dots mean the genes of the corresponding signatures marked in each panel. The blue dotted line on the x-axis means − 1 and 1 of the log₂ fold change scale, and 2 (− log₁₀(0.01)) on the y-axis.