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. 2022 Apr 15;12:6286. doi: 10.1038/s41598-022-10139-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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[¹⁷⁷Lu]Lu-DOTA-NNV003 biodistribution in RAMOS xenografted mice and comparison with [⁸⁹Zr]Zr-N-sucDf-NNV003. (A) Ex vivo biodistribution results of [¹⁷⁷Lu]Lu-DOTA-NNV003 in RAMOS-tumor bearing mice at 1 h (h), 6 h, 1 day (d) and 3 days pi. Tracer uptake per organ is presented as %ID/g. Left: [¹⁷⁷Lu]Lu-DOTA-NNV003 uptake in healthy tissues. Right: [¹⁷⁷Lu]Lu-DOTA-NNV003 uptake in tumor. (B) [⁸⁹Zr]Zr-N-sucDf-NNV003 (500 MBq/mg) and [¹⁷⁷Lu]Lu-DOTA-NNV003 (50–90 MBq/mg) ex vivo biodistribution results at 5 days pi and 3 days pi respectively. Uptake is presented as %ID/g. Data is shown as mean ± SD. **P < 0.01, *P < 0.05, ns not significant.