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. 2022 Apr 15;8:205. doi: 10.1038/s41420-022-00932-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Transwell assay of migration of HuCCT1 and HuH28 cells. B Matrigel-based Transwell assay of invasion of HuCCT1 and HuH28 cells. C Western blot assay of EMT related protein markers. In panels A-C, miR-15a-5p mimic, miR-15a-5p mimic + oe-CHEK1, si-CHEK1, and their corresponding controls were individually transfected into HuCCT1 and HuH28 cells. Cell experiments were repeated three times independently. The data are presented as mean ± standard deviation. The values at multiple groups were compared using one-way ANOVA followed by Tukey’s post-hoc tests; *means comparison against the mimic-NC group, P < 0.05; ^#means comparison against miR-15a-5p mimic + CHEK1-NC group, P < 0.05; ^&means comparison against the si-NC group, P < 0.05.