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. 2022 Apr 15;8:203. doi: 10.1038/s41420-022-00896-8

Fig. 7. Alteration of SIRT1/PTEN/EGFR axis regulates the process of OA in vivo.

Fig. 7

A qRT-PCR detection of Col2a gene expression in mouse chondrocytes in response to TGF-α and gefitinib. B qRT-PCR detection of Acan gene expression in mouse chondrocytes in response to TGF-α and gefitinib. C qRT-PCR detection of MMP-13 gene expression in mouse chondrocytes in response to TGF-α and gefitinib. D Western blot detection of MMP-13, LC3B-I, LC3B-II and Collagen protein expression in chondrocytes from mice with TGF-α and gefitinib interventions. #p < 0.05, ##p < 0.01 compared with the DMM + DMSO group. &p < 0.05, &&p < 0.01 compared with the DMM + sh-NC group. $p < 0.05, $$p < 0.01 compared with DMM + sh-SIRT1 group.