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. 2022 Apr 15;8:203. doi: 10.1038/s41420-022-00896-8

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Fig. 8 — SIRT1 inhibits the ubiquitination of EGFR by down-regulating PTEN, thereby inhibiting the degradation of extracellular matrix cartilage and activating chondrocyte autophagy, thereby conferring a protective role against OA. EMC, extracellular matrix.