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. 2022 Apr 15;12:6261. doi: 10.1038/s41598-022-10143-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased expression of genes associated with cell motility in shGPR81 cells. (a) Heatmap of differentially expressed genes in shNT and shGPR81 cells. Differentially expressed genes (false discovery rate cut off of < 0.05; minimal fold change > 1.5) were identified using the iDEP.94 database. (b) Enriched Gene Ontology clusters of downregulated genes. Gene enrichment analysis was performed using the web-based platform Metascape. Note that the positive regulation of cell motility data set showed the greatest enrichment of downregulated genes for shGPR81 cells. (c) The mRNA expression of cell motility genes in shNT and shGPR81 cells. The mRNA expression data are presented as fragments per kilobase per million mapped reads (FPKM) (mean ± s.d., n = 3/group). **p < 0.01 (vs. shNT); Student’s t-test.