Table 3. The effects of interventions on the clinical scores in the study patients .
| variable |
Melatonin
(n=30) # |
Placebo
(n=30) # |
P value * |
| RLAS-R score | |||
| Before intervention | 3 (3-5) | 4.5 (3-6) | 0.929 |
| Month 3 | 10 (6.75-10) | 10 (7.25-10) | |
| P value** | <0.001 | <0.001 | |
| mRS score | |||
| Before intervention | 5 (5-5) | 5 (5-5) | 0.137 |
| Month 3 | 3 (1-5) | 3 (0-4) | |
| P value** | <0.001 | <0.001 | |
| GCS score | |||
| Before intervention | 7 (5.75-10.50) | 7.5 (6-15) | 0.422 |
| After intervention | 9 (6-14.25) | 12 (6.75-15) | |
| P value** | <0.001 | 0.015 | |
| SOFA score | |||
| Before intervention | 6 (4-7) | 5.5 (1.75-8) | 0.462 |
| After intervention | 4 (1-6) | 3.5 (1-5.2) | |
| P value** |
<0.001 |
<0.001 |
RLAS-R: Rancho Los Amigos revised scale; mRS: modified Rankin scale; GCS: Glasgow coma scale; SOFA: sequential organ failure assessment.