Table 4. Various research findings of SLN formulations with their lipid, method of preparation, route of administration .

Drug	Route of administration	Lipid	Size	%Entrapment Efficiency	Reference
Curcumin	I.V	Compritol 888 ATO	9.51nm	-	124
CdSEe/ZnS	I.V	-	-	-	125
-	I.V	Stearic acid	159-239 nm		126
Doxorubicin	I.V	Stearic acid	80-90 ± 5 nm		101
Paclitaxel (PTX) and TOs-Cisplatin	I.V	Glyceride monostearate	108.6 ± 3.1 nm	90.3 ± 3.2%	127
Methotrexate (MTX)	I.V	Stearyl amine	174.51± 5.1 nm	84.3 ± 1.24 %	128
Nitrendipine (NDP)	I.V and Intraduodenal	Trimyristin, tripalmitin, tristearin, soy phosphatidylcholine 95%	101.9 ± 3 nm	99.8 ± 0.23 %	129
Idebenone	I.V. route	Cetyl palmitate	30 -95 nm		66
Repaglinide (RG)	Oral	Stearic acid	360± 2.5 nm (Solvent injection) 281±5.3 nm (Ultrasonication)	62.14 ± 1.29%	121
Carbamazepine	Oral	Tristearin, Phospholipon 80 H	168±1.8 nm	62.14 %	130
Elvitegravir	Oral	Gelucire 44/14	151.0±2.4- 199.1±2.7 nm	89.7±0.27%	131
Insulin	Oral	Cetyl palmitate	361±30 nm	46±6 %	105
Ramipril	Oral	Glyceryl monostearate, glyceryl monooleate	104-334 nm	72.5 ± 86.40%	132
Glibenclamide (GLI)	Oral	Precirol and compritol	105.1±2.9-183.1±3.2 nm	80±5%	133
Carvedilol (CVD)	Oral	Precirol ATO5	20±0.009 – 58±2.09 nm	78±5.17-94±3.71%	134
Buspirone HCl	Oral	Cetyl Alcohol	345.7 nm	----	135
Donepezil (DPL)	Intranasal	Glyceryl monostearate	121.0 nm	67.95%	136
Agomelatine	Intranasal	Glyceryl tripalmitate, Gelucire 43/01, Glyceryl tristeratae, Stearic acid, Precirol, and Galeol	220.90 ± 1.55-515.30±2.40 nm	58.19± 8.10-93.68 ±3.4%	117
Rifabutin (RFB)	P.A	Glyceryl dibehenate, glyceryl tristearate	92 ± 1 nm	91.2±3.6%	137
Ethambutol (EMB)	P.A	Compritol	56.25±2.05- 81.86±3.20 nm	98.16±0.66-99.04±0.4%	138
Triamcinolone acetonide	P.A	Soya lecithin	339.2 ± 1.85 nm	58.23±1.8%	119
Naringenin (NRG)	P.A	Glyceryl monostearate	98 nm	79.11%	139
Paclitaxel (PTX)	P.A				140
Avanafil (AVA)	T.D	Compritol 888, Cholesterol, Castor oil	86 nm	85.01%	108
Diclofenac Sodium (DS)	T.D			89%	141
Triptolide(TPL)	T.D	Compritol 888 ATO	104 ± 1.82 nm	92.8± 8.52%	142
Ivermectin (IVM)	T.D	Palmitic acid	312.8 ±2.4 nm	98.48± 0.052%	143
Isoniazid(INH)	O.D	Compritol 888: Stearic acid(4:1)	316.5± 8.7 nm	65.2± 2.2%	144
Natamycin (NAT)	O.D	Precirol ATO5	21.8- 47.48 nm	41.06-83.2%	145
Cyclosporine	O.D		355±11- 487±32 nm	71±1-100±1%	146
Alendronate	P.A	Compritol 888:	<100 nm	-	147
Triamcinolone Acetonide-(TA)	O.D	Stearic acid	80±11.1 nm	100%	122

T.D=Transdermal Delivery, O.D= Ocular Delivery, P.A = Pulmonary administration