Table 1. Characteristics of the Study Population by Subjective Memory Complaintsa.
| Characteristic | Participants, No. (%) | |||
|---|---|---|---|---|
| Overall (n = 900) | Subjective memory complaints | |||
| No concerns (n = 158) | Moderate concerns (n = 658) | Very worried (n = 84) | ||
| Age, mean (SD), y | 79.5 (6.2) | 78.8 (6.5) | 79.6 (6.2) | 80.2 (6.0) |
| Sex | ||||
| Female | 553 (61.4) | 96 (60.8) | 411 (62.5) | 46 (54.8) |
| Male | 347 (38.6) | 62 (39.2) | 247 (37.5) | 38 (45.2) |
| Race and ethnicity | ||||
| African American | 539 (59.9) | 86 (54.4) | 396 (60.2) | 57 (67.9) |
| Non-Hispanic White | 361 (40.1) | 72 (45.6) | 262 (39.8) | 27 (32.1) |
| Education, mean (SD), y | 13.1 (3.5) | 13.2 (3.4) | 13.1 (3.5) | 12.3 (3.5) |
| APOE4 allele | ||||
| Noncarrier | 604 (67.1) | 112 (70.9) | 441 (67.0) | 51 (60.7) |
| Carrier | 296 (32.9) | 46 (29.1) | 217 (33.0) | 33 (39.3) |
| Chronic medical conditionsb | ||||
| 0 | 193 (21.4) | 34 (21.5) | 145 (22.1) | 14 (16.6) |
| 1 | 326 (36.2) | 54 (34.2) | 247 (37.5) | 25 (29.8) |
| 2 | 261 (29.1) | 45 (28.5) | 185 (28.1) | 31 (36.9) |
| 3-6 | 120 (13.3) | 25 (15.8) | 81 (12.3) | 14 (16.7) |
| Global cognition, mean (SD), z score | 0.28 (0.59) | 0.34 (0.62) | 0.28 (0.56) | 0.17 (0.75) |
| White matter hyperintensities, geometric mean (SD) volume | 6.8 (3.9) | 5.93 (3.81) | 6.78 (3.98) | 8.59 (3.64) |
Abbreviation: APOE4, apolipoprotein e4.
a
Composed of 3 groups: participants with no concerns included those who had no memory complaints, participants with moderate concerns included those with mild memory complaints, and participants who were very worried included those with substantial memory concerns. Details of memory complaints scoring are available in the Methods.
b
Chronic medical conditions include stroke, heart disease, cancer, diabetes, hypertension, and hip fracture.