Table 3. Association of Subjective Memory Complaints With Global Cognitive Decline in Each Quartile of White Matter Hyperintensity Volumea.
| Subjective memory complaintb | White mater hyperintensity volume | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First quartile (n = 181) | Second quartile (n = 179) | Third quartile (n = 177) | Fourth quartile (n = 176) | ||||||||||
| β (95% CI)c | % of Change | P value | β (95%CI)c | % of Change | P value | β (95%CI)c | % of Change | P value | β (95%CI)c | % of Change | P value | ||
| No concerns | 0 [Reference] | NA | NA | 0 [Reference] | NA | NA | 0 [Reference] | NA | NA | 0 [Reference] | NA | NA | |
| Moderate concerns | 0.011 (−0.029 to 0.051) | 33.3 Slower | .60 | −0.030 (−0.065 to 0.006) | 93.8 Faster | .10 | −0.008 (−0.042 to 0.026) | 25 Faster | .65 | −0.018 (−0.072 to 0.035) | 100 Faster | .50 | |
| Very worried | 0.00 (−0.054 to 0.055) | 0 Slower | .99 | −0.040 (−0.097 to 0.017) | 125 Faster | .16 | −0.045 (−0.098 to 0.008) | 140.6 Faster | .09 | −0.077 (−0.144 to −0.011) | 427.8 Faster | .02 | |
Abbreviation: NA, not applicable.
a
White matter hyperintensity volumes are standardized to total cranial volume.
b
Composed of 3 groups: participants with no concerns included those who had no memory complaints, participants with moderate concerns included those with mild memory complaints, and participants who were very worried included those with substantial memory concerns. Details of memory complaints scoring are available in the Methods.
c
Model is adjusted for age, sex, race and ethnicity, education, apolipoprotein e4, and each of their interactions with time.