Table 4. Association of Subjective Memory Complaints With White Matter Hyperintensity Volume and Cognitive Decline in Model Adjusted for Chronic Medical Conditions^a.

Subjective memory complaintb	White matter hyperintensity volume		Global cognitive decline
	β (95% CI)c	P value	β (95% CI)d	P value
No concerns	0 [Reference]	NA	0 [Reference]	NA
Moderate concerns	0.283 (−0.102 to 0.668)	.15	−0.014 (−0.033 to 0.005)	.16
Very worried	0.848 (0.218 to 1.477)	.008	−0.049 (−0.076 to −0.021)	<.001

Abbreviation: NA, not applicable.

^a Chronic medical conditions include stroke, heart disease, diabetes, hypertension, and hip fracture.

^b Composed of 3 groups: participants with no concerns included those who had no memory complaints, participants with moderate concerns included those with mild memory complaints, and participants who were very worried included those with substantial memory concerns. Details of memory complaints scoring are available in the Methods.

^c Model is adjusted for age, sex, race and ethnicity, education, apolipoprotein e4, and total intracranial volume.

^d Model is adjusted for age, sex, race and ethnicity, education, apolipoprotein e4, and each of their interactions with time.