Table 1.
Clinical and pathologic characteristics
| Surgery (n=105) | Surgery+Adjuvant (n=105) | Percent difference (95% CI) | |
|---|---|---|---|
|
| |||
| Age (mean, STDEV) | 63 (10.7) | 61 (8.6) | 2.5 (0.04 to 0.91)a |
|
| |||
| Gender | |||
| Male | 84 (80) | 90 (86) | |
| Female | 21 (20) | 15 (14) | 6 (−4 to 16) |
|
| |||
| Center | |||
| 1 | 47 (45) | 46 (44) | |
| 2 | 58 (55) | 59 (56) | −1 (−14 to 12) |
|
| |||
| Smoking | |||
| No | 63 (60) | 46 (44) | |
| Yes | 42 (40) | 59 (56) | −16 (−29 to −3) |
|
| |||
| ACE-27 | |||
| None | 53 (53) | 52 (50) | 3 (−10 to 17) |
| Mild | 31 (31) | 42 (40) | −11 (−24 to 2) |
| Moderate+Severe | 16 (16) | 11 (10) | 6 (−14 to 12) |
|
| |||
| Subsite | |||
| BOT | 42 (40) | 41 (39) | |
| Tonsil | 62 (60) | 64 (61) | −1 (−14 to 12) |
|
| |||
| Treatment | NA | ||
| Surgery alone | 105 | − | |
| Adjuvant radiation | − | 43 (41) | |
| Adjuvant chemoradiation | − | 62 (59) | |
|
| |||
| ECE | |||
| No | 81 (77) | 35 (33) | |
| Yes | 24 (23) | 70 (67) | −44 (−56 to 32) |
|
| |||
| PNI | |||
| No | 100 (95) | 93 (89) | |
| Yes | 5 (5) | 12 (11) | −6 (−13 to 1) |
|
| |||
| LVI | |||
| No | 93 (89) | 85 (81) | |
| Yes | 12 (11) | 20 (19) | −8 (−18 to 2) |
|
| |||
| Margins | |||
| Negative | 104 (99) | 103 (98) | |
| Positive | 1 (1) | 2 (2) | −1 (−4 to 2) |
|
| |||
| Pathologic T Stage | NA | ||
| 1 and 2 | 90 (86) | 90 (86) | |
| 3 and 4 | 15 (14) | 15 (14) | |
|
| |||
| Lymph node | NA | ||
| <=4 | 100 (95) | 100 (95) | |
| >4 | 5 (5) | 5 (5) | |
Abbreviations: CI – Confidence interval; STDEV – Standard deviation; ACE-27 – Adult Comorbidity Evaluation-27; BOT – Base of tongue; ECE – Extracapsular extension; PNI – Perineural invasion; LVI – Lymphovascular invasion; NA – Not applicable
a
Mean difference and 95% CI