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Changes of the plasma concentration when two drugs are combined
| Drug 1/2 | Inhibitor | Substrate | Both |
|---|---|---|---|
| Inhibitor | Affect other drugs metabolized by the isozyme | Cp of Drug 1 will increase | Cp of Drug 1 will increase |
| Substrate | Cp of Drug 2 will increase | If bind the same active site, Cp of Drug 1, 2 will increase | Cp of Drug 1, 2 will increase |
| Both | Cp of Drug 2 will increase | Cp of Drug 1, 2 will increase | Cp of Drug 1, 2 will increase |
Cp: the drug concentration in plasma
