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. 2022 Apr 15;15:12. doi: 10.1186/s13072-022-00442-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Methylation status of the imprinted gene IGF2R in Sus scrofa oocytes (Oc) and ICSI-derived (IB) and mICSI-derived (MB) blastocysts. Levels of CpG methylation were calculated using the 100-CpG probe method and displayed as bar histograms in SeqMonk. Red and blue dots above each histogram indicate methylated and unmethylated C counts, respectively. Triplicate BS-seq data for each sample type are shown. Gene and CGI annotated regions are shown at the top panel. DMRs between ICSI- and mICSI-derived blastocysts from the WGBS data were determined by three DMR callers, SeqMonk (sqm), methylKit (mk) and DSS (dss), and indicated by grey boxes under the genomic features at the top part of the panel. The genomic region corresponding to the imprint control region (ICR) identified in human and mouse is indicated by the red bar at the bottom of the panel