Fig. 6.

Integration of DMRs with RNAseq results. DMRs associated with possible DEGs were identified through data filtration. A Annotated DMRs with > two-fold expression difference (log2 fold change on y-axis) and a raw p-value (< 0.05) are highlighted in red. Difference in methylation level (mICSI-derived blastocysts—ICSI-derived blastocysts %) is indicated on the x-axis. B and C Functional annotation of genes with both levels of methylation and expression affected in mICSI-derived blastocysts. B Number of genes (y-axis) with GO biological process terms in the cellular process (GO:0009987) category. C Number of genes associated with the PANTHER (http://www.pantherdb.org/) protein class categories