Table 3.
Association of candidate gene variants with HP
| All HP | Fibrotic HP | Non-fibrotic HP | Full model* (fbrotic HP) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CHR | Gene | SNP | OR | Adjusted P value | OR | Adjusted P value | OR | Adjusted P value | OR | P value |
| 3 | TERC | rs2293607 | 1.31 | 0.04 | 1.42 | 0.03 | 1.04 | 0.97 | 1.37 | 0.04 |
| 4 | FAM13A | rs2609260 | 1.35 | 0.04 | 1.29 | 0.19 | 1.63 | 0.15 | 1.29 | 0.13 |
| 5 | TERT | rs7726159 | 0.88 | 0.27 | 0.82 | 0.21 | 1.01 | 0.97 | 0.85 | 0.26 |
| 6 | DSP | rs2076295 | 1.35 | 0.02 | 1.37 | 0.03 | 1.31 | 0.43 | 1.24 | 0.10 |
| 7 | ZKSCAN1 | rs6963345 | 1.22 | 0.08 | 1.07 | 0.60 | 1.38 | 0.35 | 1.17 | 0.26 |
| 10 | OBFC1 | rs2488000 | 1.22 | 0.27 | 0.87 | 0.60 | 2.32 | 0.02 | 0.85 | 0.48 |
| 11 | MUC5B | rs35705950 | 2.11 | 1.74E-06 | 2.32 | 2.61E-06 | 1.02 | 0.97 | 2.26 | 3.56E-06 |
| 13 | ATP11A | rs1278769 | 0.72 | 0.04 | 0.81 | 0.21 | 0.46 | 0.06 | 0.81 | 0.19 |
| 15 | IVD | rs35700143 | 0.78 | 0.04 | 0.66 | 0.01 | 1.17 | 0.81 | 0.68 | 0.01 |
| 19 | DPP9 | rs12610495 | 0.94 | 0.56 | 0.82 | 0.21 | 1.01 | 0.97 | 0.72 | 0.03 |
Full model includes all 10 variants in a single logistic regression.
CHR, chromosome; HP, hypersensitivity pneumonitis; SNP, single nucleotide polymorphism.